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2 article(s) from Müller, Rainer H

BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

Florence Olechowski,
Rainer H. Müller and
Sung Min Pyo

Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208

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Figure 1: Simple representation of the structure of SmartLipids. The mixture of structurally very different s...

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Figure 2: Maximum loading reported for SLNs, NLCs and SmartLipids for the dermal active agents retinol [11-13] (left...

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Figure 3: X-ray diffraction patterns of SLNs (pink curve) and SmartLipids mixture (red curve) determined dire...

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Figure 4: Fast degradation of lipophilic active agents (R) in fluid carriers (blue), such as oil/water emulsi...

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Figure 5: Storage study with retinol loaded SmartLipids particles over six months. Remaining retinol content ...

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Figure 6: Left: Nile red-labeled lipid nanoparticle suspension (right arm) and nanoemulsion (left arm) applie...

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Figure 7: Determination of the relative film thickness by measuring the dielectric constant D on skin. Probe ...

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Figure 8: Penetration of curcumin into pig ear skin, vertical pig ear slices, fluorescence microscopy images ...

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Figure 9: Models of cosmetic active agents or drugs (green) incorporated into lipid nanoparticles, from left ...

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Figure 10: Examples of release profiles from lipid nanoparticles: very fast release of cyclosporine within min...

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Figure 11: In vitro release of the sunscreen oxybenzone from a nanoemulsion (grey) and from a SLN suspension (...

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Review

Published 04 Nov 2019

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Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

David Hespeler,
Sanaa El Nomeiri,
Jonas Kaltenbach and
Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

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Figure 1: From left to right: rutin/ethanol solution, silica dispersed in rutin solution attached to the rota...

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Figure 2: Macroscopic appearance of rutin-loaded silica powders, with decreasing agglomeration tendency from ...

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Figure 3: DSC thermograms of crystalline rutin, unloaded silica, a physical mixture of 5% rutin, to be compar...

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Figure 4: XRD of rutin, unloaded silica (SP53D), and a physical mixture (3% rutin) in comparison to the maxim...

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Figure 5: DSC thermograms (left) and XRD diffractograms (right) for selected silica nanoparticles, all loaded...

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Figure 6: Upper row: light microscopy pictures of silica XDP 3050 unloaded (left), loaded with the maximum am...

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Figure 7: Description of the silica particle loading mechanism showing the distribution of differently filled...

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Figure 8: Recovered fraction of rutin after extraction from silica SP53D (left) and 72 FP (right) with rutin ...

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Figure 9: In situ determined saturation solubility of rutin raw active agent powder (lower curves, red) and a...

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Full Research Paper

Published 08 Aug 2019

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